CVE-2026-31970: HTSlib BGZF index file reader has a heap buffer overflow

Published Mar 18, 2026
·
Updated

HTSlib is a library for reading and writing bioinformatics file formats. GZI files are used to index block-compressed GZIP [BGZF] files. In the GZI loading function, bgzfindexloadhfile(), it was possible to trigger an integer overflow, leading to an under- or zero-sized buffer being allocated to store the index. Sixteen zero bytes would then be written to this buffer, and, depending on the result of the overflow the rest of the file may also be loaded into the buffer as well. If the function did attempt to load the data, it would eventually fail due to not reading the expected number of records, and then try to free the overflowed heap buffer. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. The easiest work-around is to discard any .gzi index files from untrusted sources, and use the bgzip -r option to recreate them.

Affected Software

4 affected components
pypi/htslib<1.23
HTSlib HTSlib<1.21
HTSlib HTSlib>=1.22<1.22.2
HTSlib HTSlib=1.23

Event History

Mar 18, 2026
CVE Published
via MITRE·07:53 PM
Data Sourced
via MITRE·07:53 PM
DescriptionWeakness
Data Sourced
via NVD·08:16 PM
RemedyDescriptionSeverityWeaknessAffected Software

Frequently Asked Questions

1

What is the severity of CVE-2026-31970?

CVE-2026-31970 has a high severity rating due to the potential for remote code execution linked to a heap buffer overflow.

2

How do I fix CVE-2026-31970?

To fix CVE-2026-31970, update HTSlib to version 1.24 or later where the vulnerability has been addressed.

3

What is affected by CVE-2026-31970?

CVE-2026-31970 affects HTSlib versions up to and including 1.23 for various distributions including PyPI.

4

How does CVE-2026-31970 occur?

CVE-2026-31970 occurs due to an integer overflow in the bgzf_index_load_hfile() function when handling GZI files.

5

Who is impacted by CVE-2026-31970?

Any users or applications relying on vulnerable versions of HTSlib for bioinformatics processing are impacted by CVE-2026-31970.

Contact

SecAlerts Pty Ltd.
132 Wickham Terrace
Fortitude Valley,
QLD 4006, Australia
info@secalerts.co
By using SecAlerts services, you agree to our services end-user license agreement. This website is safeguarded by reCAPTCHA and governed by the Google Privacy Policy and Terms of Service. All names, logos, and brands of products are owned by their respective owners, and any usage of these names, logos, and brands for identification purposes only does not imply endorsement. If you possess any content that requires removal, please get in touch with us.
© 2026 SecAlerts Pty Ltd.
ABN: 70 645 966 203, ACN: 645 966 203