CVE-2026-31971: HTSlib CRAM decoder vulnerable to buffer overflow

Published Mar 18, 2026
·
Updated

HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the BYTEARRAYLEN method, the crambytearraylendecode() failed to validate that the amount of data being unpacked matched the size of the output buffer where it was to be stored. Depending on the data series being read, this could result either in a heap or a stack overflow with attacker-controlled bytes. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Affected Software

4 affected components
HTSlib HTSlib<1.21.1
HTSlib HTSlib<1.21.1
HTSlib HTSlib>=1.22<1.22.2
HTSlib HTSlib=1.23

Event History

Mar 18, 2026
CVE Published
via MITRE·07:55 PM
Data Sourced
via MITRE·07:55 PM
DescriptionWeakness
Data Sourced
via NVD·08:16 PM
RemedyDescriptionSeverityWeaknessAffected Software

Frequently Asked Questions

1

What is the severity of CVE-2026-31971?

CVE-2026-31971 is classified as a high severity vulnerability due to the potential for buffer overflow exploitation.

2

How can I fix CVE-2026-31971?

To remediate CVE-2026-31971, update HTSlib to version 1.22 or later.

3

What versions of HTSlib are affected by CVE-2026-31971?

HTSlib versions prior to 1.22 and including 1.23 are affected by CVE-2026-31971.

4

What type of vulnerability is CVE-2026-31971?

CVE-2026-31971 is a buffer overflow vulnerability in the HTSlib CRAM decoder.

5

What can attackers potentially do by exploiting CVE-2026-31971?

Exploiting CVE-2026-31971 could allow attackers to execute arbitrary code or crash applications using the vulnerable HTSlib library.

Contact

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