Bitcoin Core 0.12.0 through 0.21.1 does not properly implement the replacement policy specified in BIP125, which makes it easier for attackers to trigger a loss of funds, or a denial of service attack against downstream projects such as Lightning network nodes. An unconfirmed child transaction with nSequence = 0xffffffff, spending an unconfirmed parent with nSequence <= 0xfffffffd, should be replaceable because there is inherited signaling by the child transaction. However, the actual PreChecks implementation does not enforce this. Instead, mempool rejects the replacement attempt of the unconfirmed child transaction.
Bitcoin Core 0.12.0 through 0.17.1 and Bitcoin Knots 0.12.0 through 0.17.x before 0.17.1.knots20181229 have Incorrect Access Control. Local users can exploit this to steal currency by binding the RPC IPv4 localhost port, and forwarding requests to the IPv6 localhost port.