CiviCRM 4.0.5 and 4.1.1 does not verify that the server hostname matches a domain name in the subject's Common Name (CN) or subjectAltName field of the X.509 certificate, which allows man-in-the-middle attackers to spoof SSL servers via an arbitrary valid certificate.
CiviCRM 2.0.0 through 4.2.9 and 4.3.0 through 4.3.3 does not properly enforce role-based access control (RBAC) restrictions for default custom searches, which allows remote authenticated users with the "access CiviCRM" permission to bypass intended access restrictions, as demonstrated by accessing custom contribution data without having the "access CiviContribute" permission.