Undisclosed requests can cause the Traffic Management Microkernel (TMM) to terminate when a client-side HTTP/2 profile and the HTTP MRF Router option are enabled for a virtual server and an iRule using the HTTPREQUEST event or Local Traffic Policy are associated with the virtual server. TMM can also terminate when a client-side HTTP/2 profile and the HTTP MRF Router option are enabled, regardless of the presence of the iRule.