Irssi before 0.8.15, when SSL is used, does not verify that the server hostname matches a domain name in the subject's Common Name (CN) field or a Subject Alternative Name field of the X.509 certificate, which allows man-in-the-middle attackers to spoof IRC servers via an arbitrary certificate.
Off-by-one error in the eventwallops function in fe-common/irc/fe-events.c in irssi 0.8.13 allows remote IRC servers to cause a denial of service (crash) via an empty command, which triggers a one-byte buffer under-read and a one-byte buffer underflow.
core/nicklist.c in Irssi before 0.8.15 allows remote attackers to cause a denial of service (NULL pointer dereference and application crash) via vectors related to an attempted fuzzy nick match at the instant that a victim leaves a channel.